Webinars

Inhalation Sciences Webinar Report: 28 May 2025

DissolvIt – Evaluation Report and Presentation of Data from the FDA Funded Study on Inhalation Sciences In-Vitro Module, DissolvIt

Webinar Abstract

The DissolvIt® dissolution method for inhaled drug powders provides two sets of data for the better understanding of drug dissolution and absorption in the lungs; one more detailed set of time-resolved data including predictions on tmax and cmax concentrations, and; one cumulative dissolution data set similar to those of conventional methods. DissolvIt® provides simulated kinetic dissolution/absorption data akin to those of more complex ex vivo or in vivo experiments in animals. One beneficial aspect of the DissolvIt® data is to reproduce smaller differences and more rapid events in the dissolution process, not observable in other methods. The more physiological basis of the DissolvIt® data provides ample opportunities on advising kinetic in silico models for improved clinical predictions.

You’ll discover how DissolvIt®:

  • Provides two types of data to better understand lung absorption: time-resolved data and cumulative dissolution data.
  • Simulates kinetic dissolution and absorption similar to ex vivo/in vivo models
  • Detects small differences and rapid events missed by conventional methods
  • Provides a physiological basis for more realistic lung modeling
  • Supports in silico kinetic models to improve clinical prediction accuracy

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Inhalation Sciences Webinar Report: 11 December 2024

Regional Lung Targeting with PreciseInhale® A Feasibility Study in Humans
Paolo and Eunice introduced a webinar session on regional long targeting with Precise Inhale, highlighting its advantages and efficiency in delivering aerosols to the lungs. The meeting also discussed the setup and execution of a clinical trial involving healthy volunteers, the importance of identifying and mitigating risks, and the challenges faced during the trial. Lastly, the team discussed the modality of inhalation with a precise inhale, the aerosol parameters, and the potential of using gamma sintigraphy imaging for precise quantification of regional deposition patterns within the lungs.

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Inhalation Sciences Webinar Report: 4 December 2024

Does My Drug Have a Chance for Inhaled Delivery?
The meeting focused on the potential of inhaled drug delivery, with discussions on APIs, the possibilities for success in inhalation as a delivery route, and a case study on isolated perfused lungs. The team also explored the use of non-clinical in vivo data, the precise inhaler generator, and the isolated perfused lung system in understanding drug behavior and metabolism in the lungs. The conversation ended with a discussion on the substances studied, the use of the Ipl system in toxicology practice, and the announcement of an upcoming webinar.

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Large-lung models: 21 May 2024

Translation of Inhaled Exposures throughout Drug Development
In this webinar, ISAB CSO Per Gerde is joined by Rebecca Fransson (Principal Scientist in Biopharmaceutics at AstraZeneca), Steven Oag (Director of Animal Science and Technologies, AstraZeneca) and Pär Ewing (DMPK Design Lead, AstraZeneca) who discuss how to:

  • usea large-lung preclinical model to generate preclinical in vivo data
  • reduce translational errors through drug development using this method
  • carry out single-animal Nose-only and intra-Tracheal exposures using one-animal-at-a-time precision dosing on the PreciseInhale system

(Recording not available)

Inhaled biologics: 11 December 2023

Realization and Preclinical Testing of Dry Powder Formulations
In this webinar, Per Gerde and Paolo Raffaelli, CSO and CCO respectively of Inhalation Sciences, with Ann Gidner and Xavier Turon, CEO and COO respectively from Ziccum, will discuss how to:

  • Turn your biologic therapy into a stable dry powder at room temperature
  • Generate actionable preclinical data to calibrate successive steps and consolidate your investor pitch
  • Get insight into lung retention and PK curves for your dry powder biologics

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In vitro webinar: 30 March 2023

The DissolvIt Dissolution Method Case Study and Bioanalysis of Inhaled
In this webinar, Maria MaImlof, Ph.D., Director of Project and in vitro Specialist, Inhalation Sciences Sweden AB, and Prof. Hermann Mascher, Founder of pharm-analyt Labor GmbH and Bioanalytical Consultant, discuss the following:

  • How the DissolvIt dissolution method can generate PK curves similar to in vivo or human studies.
  • How the DissolvIt method provides strong discriminative power across APIs, formulations, physical forms, and physiologically relevant data.
  • A case study on Glycopyrronium and Indacaterol using the DissolvIt® method.
  • Bioanalysis of small-volume DissolvIt samples with low LLOQs.

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