In vivo webinar: 2 May 2023

Human and Nonclinical Translational Dose Implications in Respiratory Drug Development
In this webinar, Matt Reed, PhD, principal at Coelus Bio, and Per Gerde, founder at CSO at Inhalation Sciences discuss how to:

  • Generate a clinical dose estimate on the basis of preclinical data.
  • Describe a specific example of generating a clinical dose for an antibiotic delivered via a nebulizer.
  • How the rodent models are accurate for tidal breathing preclinical exposures and clinical exposures through nebulizers.
  • For bolus delivery, a large lung model is necessary for a smoother translational exercise.

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In vitro webinar: 30 March 2023

The DissolvIt Dissolution Method Case Study and Bioanalysis of Inhaled
In this webinar, Maria MaImlof, Ph.D., Director of Project and in vitro Specialist, Inhalation Sciences Sweden AB, and Prof. Hermann Mascher, Founder of pharm-analyt Labor GmbH and Bioanalytical Consultant, discuss the following:

  • How the DissolvIt dissolution method can generate PK curves similar to in vivo or human studies.
  • How the DissolvIt method provides strong discriminative power across APIs, formulations, physical forms, and physiologically relevant data.
  • A case study on Glycopyrronium and Indacaterol using the DissolvIt® method.
  • Bioanalysis of small-volume DissolvIt samples with low LLOQs.

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