PK studies
Advanced PK studies for a more solid in vitro-in vivo correlation.
From in vitro unique tests to cell exposure at the air-liquid interface, in vitro-in vivo correlation starts early with Inhalation Sciences’ PK data and continues with accurate in vivo rodent and large lung models, complemented with the Isolated Perfused Lung method, which allows frequent sampling and smooth curves for a complete understanding of the compound’s PK behavior.
Aerosolization Characterization - Aerodynamic Particle Size Distribution
Dissolution curves In vitro – artificial mucus In vitro dissolution tests
Permeability curves In vitro – cells exposed at the Air-Liquid Interface
Lung retention, perfusate levels, PK curves Ex vivo – Isolated Perfused Lung – rat model
Plasma levels, PK curves In vivo, rodents and large lung models
