ISAB talks bioaerosols in Tours
Bioaerosols: What will be the biological effects? On September 4-9 ISAB took PreciseInhale to Tours in central France for the European Aerosol Assembly’s (EAA’s) 2016 Conference. Interest was high in ISAB’s in vitro capabilities for tracing the biological effects of inhaled bioaerosols in the lung.
The world is growing – and so is the amount of waste it composts. Each time compost is turned or shredded it releases bioaerosol particles into the atmosphere that many inhale. What are the potentially hazardous biological effects? This is only one example of bioaerosols being widely discussed at the EAA Aerosol conference 2016.
ISAB CEO Fredrik Sjövall: “Whilst some are in the process of capturing these small amounts of materials and characterizing them, key challenges remain. How can we measure the biological behaviour of these aerosols in the lung? How does exposure differ between residents living nearby to composting plants, and people inhaling it from a wider dispersal? What are the characteristics of the dose response? What are their specific characteristics? These are fascinating areas.”
The Conference focused on five major areas: aerosol technology, atmospheric aerosol studies, aerosol measurement techniques, aerosols and health and basic aerosol processes. Within these areas bioaerosols recurred as a key priority for many.
ISAB has worked identifying and mapping the behaviour of toxic bioaerosols previously, including projects examining the effects of pig dust inhaled by pig farmers. ISAB’s technology offers environmental and tox scientists exploring bioaerosols several key benefits:
Exceptionally close in vitro modelling of biological effects of bioaerosols
XposeALI, Inhalation Sciences’ in vitro cell exposure module combines aerosol capability with 3D cell models cultured in an Air Liquid Interface (ALI.) It allows in vitro dissolution monitoring, and its dynamic perfusion system more closely resembles the physiology of the living lung than conventional static systems.
3R regulatory requirements met
Replacing, refining and reducing the number of animals in research is crucial to much funding of toxicological and environmental research. PreciseInhale’s two in vitro modules replace animal testing, allowing researchers to meet 3R requirements.
Expertise and experience
Toxicological and environmental research is in ISAB’s DNA. PreciseInhale was originally developed for research into radioactive diesel dust dosimetry in the lungs, at the Lovelace Respiratory Research Institute in the US. With our experience of risk assessment of carcinogenic substances, for toxicologist and environmental researchers, working with ISAB means working with seasoned experts who know their issues.